Fully automatic cervical vertebrae segmentation framework for X-ray images. (April 2018)

• Record Type: Journal Article
• Authors: Al Arif, S. M. Masudur Rahman; Knapp, Karen; Slabaugh, Greg
• Is Part Of: Computer methods and programs in biomedicine. Volume 157(2018)
• Page Start: 95
• Page End: 111
• Publication Date: 2018-04
• Subjects: Segmentation -- Deep learning -- FCN -- UNet -- Localization -- Cervical vertebrae -- X-ray; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2018.01.006
• Languages: English
• ISSNs: 0169-2607

Abstract

Highlights: A deep segmentation network based spine localization algorithm which outperforms the previous state-of-the-art by a large margin. A novel spatial probability prediction deep convolutional network which achieves human-level performance in localizing vertebrae centers. A novel shape-aware deep segmentation network for vertebrae segmentation. A first of its kind fully automatic framework which combines the global localization, center localization and vertebrae segmentation in a single thread and provides a segmentation result for a real-life emergency room X-ray images without any manual input. Abstract: The cervical spine is a highly flexible anatomy and therefore vulnerable to injuries. Unfortunately, a large number of injuries in lateral cervical X-ray images remain undiagnosed due to human errors. Computer-aided injury detection has the potential to reduce the risk of misdiagnosis. Towards building an automatic injury detection system, in this paper, we propose a deep learning-based fully automatic framework for segmentation of cervical vertebrae in X-ray images. The framework first localizes the spinal region in the image using a deep fully convolutional neural network. Then vertebra centers are localized using a novel deep probabilistic spatial regression network. Finally, a novel shape-aware deep segmentation network is used to segment the vertebrae in the image. The framework can take an X-ray image and produce a vertebrae segmentation result without any manual intervention. Each block of the fully automatic framework has been trained on a set of 124 X-ray images and tested on another 172 images, all collected from real-life hospital emergency rooms. A Dice similarity coefficient of 0.84 and a shape error of 1.69 mm have been achieved.