One-pot synthesis of albumin-gadolinium stabilized polypyrrole nanotheranostic agent for magnetic resonance imaging guided photothermal therapy. (April 2018)

• Record Type: Journal Article
• Authors: Yang, Zhe; He, Wenshan; Zheng, Hongyi; Wei, Jielin; Liu, Pei; Zhu, Wei; Lin, Leping; Zhang, Li; Yi, Changfeng; Xu, Zushun; Ren, Jinghua
• Is Part Of: Biomaterials. Volume 161(2018)
• Page Start: 1
• Page End: 10
• Publication Date: 2018-04
• Subjects: Polypyrrole -- Photothermal therapy -- Biomimetic mineralization -- MRI; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2018.01.026
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Theranostic agents with perfect properties are needed urgently for the development of imaging guided photothermal therapy (PTT). In this work, Gd-integrated polypyrrole nanotheranostic agent (PPy@BSA-Gd) was successfully built through selecting bovine serum albumin (BSA) as both stabilizers for polymerization and biomimetic mineralization in "one pot". The obtained PPy@BSA-Gd possessed high stability and excellent photothermal property. Besides, relevant cellular assays indicated that PPy@BSA-Gd had fantastic cytocompatibility which could be further internalized by cancer cells. Due to their high longitudinal relaxivity value (r1 = 10.203 mM −1 s −1 ), PPy@BSA-Gd could serve as considerable probe for T1 -weighted magnetic resonance imaging (MRI). After tail vein injection of PPy@BSA-Gd, the MR signal of tumor section exhibited a time-dependent increase, indicating effective tumor accumulation of PPy@BSA-Gd. Notably, when exposed to 808 nm laser, the tumor growth of PPy@BSA-Gd treated mice could be inhibited by photothermal ablation successfully. All the results demonstrated the well-designed PPy@BSA-Gd have the potential for tumor diagnose and photothermal therapy.