3‐Aminoindole Synthesis from 2‐Nitrochalcones and Ammonia or Primary Amines. Issue 16 (3rd July 2019)

• Record Type: Journal Article
• Authors: Zhang, Guan; Lin, Lu; Yang, Kai; Wang, Shihui; Feng, Qiang; Zhu, Jun; Song, Qiuling
• Is Part Of: Advanced synthesis & catalysis. Volume 361:Issue 16(2019)
• Page Start: 3718
• Page End: 3722
• Publication Date: 2019-07-03
• Subjects: 3-aminoindole -- 2-nitrochalcone -- ammonia -- primary amines -- metal-free; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201900551
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A step‐economic strategy for 3‐aminoindoles synthesis with ammonia or primary amines as "N" source under transition‐metal‐free conditions was achieved. A series of 3‐aminoindoles was obtained with abundant "N" source featuring high efficiency, mild conditions, environmental friendliness and scalability. Efficient syntheses of the intermediates of COX‐2 inhibitor and tubulin polymerization inhibitor were successfully accomplished with this newly developed strategy. Abstract :