A practical method for heterogeneously-catalyzed Mizoroki–Heck reaction: Flow system with adjustment of microwave resonance as an energy source. Issue 15 (12th April 2018)

• Record Type: Journal Article
• Authors: Ichikawa, Tomohiro; Mizuno, Masahiro; Ueda, Shun; Ohneda, Noriyuki; Odajima, Hiromichi; Sawama, Yoshinari; Monguchi, Yasunari; Sajiki, Hironao
• Is Part Of: Tetrahedron. Volume 74:Issue 15(2018)
• Page Start: 1810
• Page End: 1816
• Publication Date: 2018-04-12
• Subjects: Heck reaction -- Heterogeneous catalysis -- Microwave chemistry -- Palladium -- Polymers; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2018.02.044
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: The microwave-assisted and continuous-flow Mizoroki–Heck reaction using a heterogeneous palladium catalyst supported on the anion-exchange resin DIAION WA30 (7% Pd/WA30) is described. The microwave resonance is finely adjusted to 2.4 GHz according to the electric permittivity of the reaction medium for efficient heating. Organic solvents, such as acetonitrile, N, N -dimethylacetamide, and toluene, can be sufficiently heated even with a low intensity of microwave irradiation in a 7% Pd/WA30-packed, glass tube-shaped catalyst cartridge, which was designed based on the electric permittivity of the solvents. The catalyst cartridge can be continuously reused at least 5 runs without exchange. Graphical abstract: