Antimicrobial activity of simplified mimics of celogentin C. Issue 12 (22nd March 2018)
- Record Type:
- Journal Article
- Title:
- Antimicrobial activity of simplified mimics of celogentin C. Issue 12 (22nd March 2018)
- Main Title:
- Antimicrobial activity of simplified mimics of celogentin C
- Authors:
- Thombare, Varsha J.
Holden, James A.
Pal, Sreetama
Reynolds, Eric C.
Chattopadhyay, Amitabha
O'Brien-Simpson, Neil M.
Hutton, Craig A. - Abstract:
- Abstract: Linear and bicyclic analogues of the peptide natural product, celogentin C, have been prepared in which the sidechain–sidechain crosslinks in celogentin are omitted or replaced with a mesitylenyl moiety. The simplified bicyclic peptides display moderate antibacterial activity, potentially through inhibition of bacterial protomicrotubule formation, while the linear analogs show higher antibacterial activity through a possible membrane disruption mechanism. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 74:Issue 12(2018)
- Journal:
- Tetrahedron
- Issue:
- Volume 74:Issue 12(2018)
- Issue Display:
- Volume 74, Issue 12 (2018)
- Year:
- 2018
- Volume:
- 74
- Issue:
- 12
- Issue Sort Value:
- 2018-0074-0012-0000
- Page Start:
- 1288
- Page End:
- 1293
- Publication Date:
- 2018-03-22
- Subjects:
- Celogentin -- Antimicrobial peptides -- Stapled peptides -- Cyclic peptides
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2017.12.032 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 11417.xml