Bayesian ROC curve estimation under verification bias. (1st October 2014)

• Record Type: Journal Article
• Authors: Gu, Jiezhun; Ghosal, Subhashis; Kleiner, David E.
• Is Part Of: Statistics in medicine. Volume 33:Number 29(2014)
• Page Start: 5081
• Page End: 5096
• Publication Date: 2014-10-01
• Subjects: binormal model -- MAR assumption -- posterior consistency -- ROC curve -- verification bias‐correction; Medical statistics -- Periodicals; Statistique médicale -- Périodiques; Statistiques médicales -- Périodiques; 610.727
• DOI: 10.1002/sim.6297
• Languages: English
• ISSNs: 0277-6715

Abstract

Abstract : Receiver operating characteristic (ROC) curve has been widely used in medical science for its ability to measure the accuracy of diagnostic tests under the gold standard. However, in a complicated medical practice, a gold standard test can be invasive, expensive, and its result may not always be available for all the subjects under study. Thus, a gold standard test is implemented only when it is necessary and possible. This leads to the so‐called 'verification bias', meaning that subjects with verified disease status (also called label) are not selected in a completely random fashion. In this paper, we propose a new Bayesian approach for estimating an ROC curve based on continuous data following the popular semiparametric binormal model in the presence of verification bias. By using a rank‐based likelihood, and following Gibbs sampling techniques, we compute the posterior distribution of the binormal parameters intercept and slope, as well as the area under the curve by imputing the missing labels within Markov Chain Monte‐Carlo iterations. Consistency of the resulting posterior under mild conditions is also established. We compare the new method with other comparable methods and conclude that our estimator performs well in terms of accuracy. Copyright © 2014 John Wiley & Sons, Ltd.