Benzophenanthridine alkaloids from the roots of Thalictrum microgynum Lecoy.ex Oliv. Issue 20 (18th October 2019)

• Record Type: Journal Article
• Authors: Jiang, Jie; Ma, Haoran; Hu, Song; Cheng, Lu; Wang, Fuqian; Zhang, Geng
• Is Part Of: Natural product research. Volume 33:Issue 20(2019)
• Page Start: 2964
• Page End: 2969
• Publication Date: 2019-10-18
• Subjects: Buttercup family -- Thalictrum genus -- Thalictrum microgynum Lecoy.ex Oliv -- benzophenanthridine alkaloid; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1512991
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new benzophenanthridine alkaloid, 2, 3, 9-trimethoxy-7, 8-methylenedioxy-5-methylbenzo[c]-6(5H) phenanthridone (2 ) and a benzophenanthridine alkaloid first found from natural sources, 2, 3-dimethoxy-7, 8- methylenedioxy-5-methylbenzo[c]-6(5H)- phenanthridone (1 ) together with two known benzophenanthridine alkaloids, Dihydrosanguinarine (3 ) and Dihydrochelilutine (4 ) were isolated from the roots of Thalictrum microgynum Lecoy.ex Oliv. The structures of1 and2 were elucidated using various spectroscopic techniques including HRESIMS and 1 D and 2 D NMR. Antibacterial activity of these compounds were tested. Compound1, 3 and4 showed antibacterial activity against Staphylococcus aureus with MIC values of 50, 100, 25 μg/mL, respectively. Graphical Abstract: