Expression of Interleukin-1 and temporomandibular disorder: Contemporary review of the literature. Issue 4 (4th July 2018)

• Record Type: Journal Article
• Authors: Sorenson, Adam; Hresko, Kyle; Butcher, Seth; Pierce, Sean; Tramontina, Vinicius; Leonardi, Rosalia; Loreto, Carla; Bosio, Jose; Almeida, Luis Eduardo
• Is Part Of: Cranio. Volume 36:Issue 4(2018)
• Page Start: 268
• Page End: 272
• Publication Date: 2018-07-04
• Subjects: Temporomandibular joint -- Interleukin-1 -- temporomandibular joint disorder; Temporomandibular joint disorders -- periodicals; Temporomandibular joint -- Diseases -- Periodicals; 617.51
• DOI: 10.1080/08869634.2017.1342890
• Languages: English
• ISSNs: 0886-9634

Abstract

Abstract: Objective : Temporomandibular disorders (TMD) are a group of conditions affecting the temporomandibular joint (TMJ), leading to jaw dysfunction, joint and muscle pain, and a decrease in quality of life. A communication network of pro- and anti-inflammatory mediators called cytokines maintains the homeostasis of the TMJ. This review will focus on the Interleukin (IL) family of cytokines, which have been quantified in TMJ synovial fluids in a variety of studies. IL-1α and IL-1β have pro-inflammatory effects, while the endogenous receptor antagonist (IL-1RA) inhibits the pro-inflammatory effects of IL-1. Methods : A literature search (2006–2016) to identify eligible studies was completed using the PubMed database. Studies identified used saline irrigation to quantify cytokine profiles in synovial fluid of healthy and/or dysfunctional joints. Results : The initial search yielded 111 articles, 5 of which met the inclusion criteria after inter-reviewer discussion. Conclusions : Articles that compared IL-1 concentrations in TMD vs. control groups found significant differences.