Functional Group Effects of New Calixarene Derivatives on Catalytic and Enantioselective Behavior of Lipase. (8th August 2019)

• Record Type: Journal Article
• Authors: Dogan, Vildan; Sayin, Serkan; Uyanik, Arzu; Yilmaz, Mustafa
• Is Part Of: Polycyclic aromatic compounds. Volume 39:Number 4(2019)
• Page Start: 318
• Page End: 331
• Publication Date: 2019-08-08
• Subjects: Calixarene -- enantioselectivity -- Fe3O4nanoparticles -- flurbiprofen -- lipase; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2017.1326949
• Languages: English
• ISSNs: 1040-6638

Abstract

ABSTRACT: In this study, two new calixarene derivatives bearing thiourea and carbamate moieties were synthesized and characterized. Moreover, thiourea- and carbamate-bridged calixarene derivatives with Fe3 O4 magnetic nanoparticle were employed for the first time as the convenient additives in the encapsulation process of lipase. The results of catalytic activity and enantioselectivity of the encapsulated lipases in the hydrolysis reaction of racemic flurbiprofen methyl ester indicate that both of the encapsulated lipases (Enc-TuC[4]@Fe3 O4 andEnc-CbC[4]@Fe3 O4 ) exhibit higher conversion and enantioselectivity compared to the free-encapsulated lipase (Enc-Lipase ). However, the highest affinities result was obtained when the encapsulated lipase (Enc-CbC[4]@Fe3 O4 ) was used in the kinetic resolution reaction of racemic flurbiprofen methyl ester.