Three new labdane-type diterpenoids from Callicarpa macrophylla Vahl. Issue 20 (18th October 2019)

• Record Type: Journal Article
• Authors: Wang, Zhen-Hui; Xu, Huan-Jun; Zhai, Yang-Yang; Yang, Lan-Ping; Li, Qiang; Huang, Mei; Chen, Xing-Ying; Zhang, Wen-Kui; Meng, Yue-Li; Zhang, Qing-Ling; Niu, Chao; Zhang, Yan-Ru
• Is Part Of: Natural product research. Volume 33:Issue 20(2019)
• Page Start: 2904
• Page End: 2910
• Publication Date: 2019-10-18
• Subjects: Callicarpa macrophylla Vahl. -- labdane-type diterpenoids -- NO inhibition; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1509336
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new labdane-type diterpenoids, callicapene M3-M5 (1–3 ) were isolated from the Callicarpa macrophylla Vahl. Their structures were identified by spectroscopic method. The isolated compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds1 –3 showed potent inhibitory activity, with IC50 value of 48.15, 46.31 and 38.72 μM respectively. GRAPHIC ABSTRACT: