A new indole-type alkaloid from the roots of Clematis florida var. plena. Issue 20 (18th October 2019)

• Record Type: Journal Article
• Authors: Sun, Kai-Hui; Ma, Xin-Hua; Zeng, Xian-Ming; Lin, Zhong-Yue; Cai, Yu-Mei; Zhang, Hai-Tao; Lin, Xiao-Yan; Feng, Shi-Biao; Zhong, Tian-Hua; Zhang, Yong-Hong
• Is Part Of: Natural product research. Volume 33:Issue 20(2019)
• Page Start: 2925
• Page End: 2931
• Publication Date: 2019-10-18
• Subjects: Clematis florida var. plena -- alkaloid -- saponins -- anti-inflammatory; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1510396
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new indole-type alkaloid, α -L-rhamnopyranosyl-(1→6)- β -D- glucopyranosyl 6-methoxy-3-indolecarbonate (1 ), together with three known alkaloids (2 –4 ), one aromatic acid (5 ) and five known saponins (6 –10 ), was isolated from the roots of Clematis florida var. plena . Their structures were established by NMR spectroscopic analysis and acid hydrolysis. In in vivo anti-inflammatory activity, n -butanol extract was found to be potent against ear edema in mice, with inhibition rate of 48.7% at a dose of 800 mg/kg. Furthermore, compounds8 and9 obtained from the n -butanol extract exhibited significant anti-inflammatory activities with inhibition rates of 50.9% and 54.7% at a dose of 200 mg/kg. Graphical Abstract: