Penicindopene A, a new indole diterpene from the deep-sea fungus Penicillium sp. YPCMAC1. Issue 20 (18th October 2019)

• Record Type: Journal Article
• Authors: Liu, Lijun; Xu, Wei; Li, Shumin; Chen, Mengying; Cheng, Yongjun; Yuan, Wangjun; Cheng, Zhongbin; Li, Qin
• Is Part Of: Natural product research. Volume 33:Issue 20(2019)
• Page Start: 2988
• Page End: 2994
• Publication Date: 2019-10-18
• Subjects: Indole diterpene -- deep-sea fungus -- Penicillium sp. YPCMAC1 -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1514402
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new indole diterpene, named penicindopene A (1 ), together with seven known compounds (2 – 8 ), was isolated from the deep-sea fungus Penicillium sp. YPCMAC1. The structure of penicindopene A was elucidated by extensive spectroscopic analyses (1 D and 2 D NMR, and HRESIMS data), in addition to the ECD calculations for the assignments of its absolute configuration. Penicindopene A represented the first example of indole diterpenes possessing a 3-hydroxyl-2-indolone moiety, and it exhibited moderate cytotoxicities against A549 and HeLa cell lines with IC50 values of 15.2 and 20.5 µ M, respectively. Graphical Abstract: