Ruthenium-catalyzed remote C5-sulfonation of N-alkyl-8-aminoquinolines. Issue 32 (2nd August 2019)

• Record Type: Journal Article
• Authors: Liu, Xuri; Zhang, Han; Yang, Fanzhi; Wang, Bo
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 32(2019)
• Page Start: 7564
• Page End: 7568
• Publication Date: 2019-08-02
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob01357a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Ruthenium-catalyzed remote C–H sulfonation of 8-aminoquinolines with single C5-selectivity. Abstract : There is an increasing demand for the methodologies of positionally selective remote C–H functionalizations. We herein report the ruthenium-catalyzed remote C5-selective sulfonation of 8-aminoquinoline derivatives. Moderate to high yields were obtained with different substituted substrates. The catalytic system exhibited a high regio-selectivity, as well as good functional group tolerance. Mechanistic study supported a radical pathway. A bifunctional ruthenium-catalytic cycle is proposed.