Trapping of sub-100 nm nanoparticles using gigahertz acoustofluidic tweezers for biosensing applications. Issue 31 (26th June 2019)

• Record Type: Journal Article
• Authors: Cui, Weiwei; Mu, Luye; Duan, Xuexin; Pang, Wei; Reed, Mark A.
• Is Part Of: Nanoscale. Volume 11:Issue 31(2019)
• Page Start: 14625
• Page End: 14634
• Publication Date: 2019-06-26
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nr03529j
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : In this study, we present a nanoscale acoustofluidic trap (AFT) that enables a simple, no-wash, and practical approach for biosensing applications. Abstract : In this study, we present a nanoscale acoustofluidic trap (AFT) that manipulates nanoparticles in a microfluidic system actuated by a gigahertz acoustic resonator. The AFT generates independent standing closed vortices with high-speed rotation. Via careful design and optimization of geometric confinements, the AFT was able to effectively capture and enrich sub-100 nm nanoparticles with a low power consumption (0.25–5 μW μm −2 ) and rapid trapping (within 30 s), showing significantly enhanced particle-operating ability as compared to its acoustic and optical counterparts; using specifically functionalized nanoparticles (SFNPs) to selectively capture target molecules from the sample, the AFT led to the molecular concentration enhancement of ∼200 times. We investigated the feasibility of the SFNP-assisted AFT preconcentration method for biosensing applications and successfully demonstrated the capability of this method for the detection of serum prostate-specific antigen (PSA). The AFT was prepared via a fully CMOS-compatible process and thus could be conveniently integrated on a single chip, with potential for "lab-on-a-chip" or point-of-care (POC) nanoparticle-based biosensing applications.