Effects of dispersible MoS2 nanosheets and Nano-silver coexistence on the metabolome of yeast. (May 2018)

• Record Type: Journal Article
• Authors: Yang, Qi; Zhang, Lei; Ben, Ailing; Wu, Na; Yi, Yanliang; Jiang, Ling; Huang, He; Yu, Yadong
• Is Part Of: Chemosphere. Volume 198(2018)
• Page Start: 216
• Page End: 225
• Publication Date: 2018-05
• Subjects: Molybdenum disulfide -- Nano-silver -- Co-contamination -- Ecotoxicity -- Nanotoxicity -- Metabonomics; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2018.01.140
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: As a new rising star in the post-graphene two-dimensional materials (2DMs), molybdenum disulfide (MoS2 ) attracts increasing attentions and is widely applied. However, the chemical and toxicological interaction between MoS2 and other co-contaminants is still poorly understood. Nano-silver (N-Ag) is the most commonly used nanomaterial in commercial products and distributed widely in the environment. Herein, we investigated the effects of chitosan functionalized MoS2 (CS-MoS2 ) nanosheets, a water-dispersible form of MoS2, on the microbial toxicity of N-Ag. We found that the incorporation of CS-MoS2 nanosheets attenuated the oxidative stress induced by N-Ag on yeast cells, while caused more membrane stress. In addition, the inhibition of N-Ag on the metabolic activities of yeast cells could be attenuated by CS-MoS2 nanosheets as well. The coexistence of N-Ag and CS-MoS2 nanosheets mainly perturbed the amino acid-related metabolic pathways in yeast cells, and phosphoric acid was a potential nanotoxicity biomarker. We further found that CS-MoS2 nanosheets dramatically absorbed the Ag ion released from N-Ag, which might be responsible for its attenuation effect on the microbial toxicity of N-Ag. Our findings provide more new insights for the ecotoxicity evaluation of MoS2 and other 2DMs. Graphical abstract: Highlights: Coexistence of CS-MoS2 nanosheets and N-Ag perturbed the metabolome of yeast. CS-MoS2 nanosheets absorbed the released Ag + and attenuated oxidative stress. CS-MoS2 nanosheets caused more membrane damages in yeast cells.