Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging. Issue 43 (9th August 2019)

• Record Type: Journal Article
• Authors: Thakare, Vivek; Tran, Vu-Long; Natuzzi, Marco; Thomas, Eloïse; Moreau, Mathieu; Romieu, Anthony; Collin, Bertrand; Courteau, Alan; Vrigneaud, Jean-Marc; Louis, Cédric; Roux, Stéphane; Boschetti, Frédéric; Tillement, Olivier; Lux, François; Denat, Franck
• Is Part Of: RSC advances. Volume 9:Issue 43(2019)
• Page Start: 24811
• Page End: 24815
• Publication Date: 2019-08-09
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra00365g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The controlled dual functionalization of AGuIX® nanoparticles afforded trimodal imaging (PET/MRI/fluorescence) theranostic agents. Abstract : A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with 64 Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.