Tailored therapeutics based on 1, 2, 3-1H-triazoles: a mini review. Issue 8 (31st May 2019)

• Record Type: Journal Article
• Authors: Prasher, Parteek; Sharma, Mousmee
• Is Part Of: MedChemComm. Volume 10:Issue 8(2019)
• Page Start: 1302
• Page End: 1328
• Publication Date: 2019-05-31
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c9md00218a
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : Contemporary drug discovery approaches rely on library synthesis coupled with combinatorial methods and high-throughput screening to identify leads. Abstract : Contemporary drug discovery approaches rely on library synthesis coupled with combinatorial methods and high-throughput screening to identify leads. However, due to the multitude of components involved, a majority of optimization techniques face persistent challenges related to the efficiency of synthetic processes and the purity of compound libraries. These methods have recently found an upgradation as fragment-based approaches for target-guided synthesis of lead molecules with active involvement of their biological target. The click chemistry approach serves as a promising tool for tailoring the therapeutically relevant biomolecules of interest, improving their bioavailability and bioactivity and redirecting them as efficacious drugs. 1, 2, 3-1 H -Triazole nucleus, being a planar and biologically acceptable scaffold, plays a crucial role in the design of biomolecular mimetics and tailor-made molecules with therapeutic relevance. This versatile scaffold also forms an integral part of the current fragment-based approaches for drug design, kinetic target guided synthesis and bioorthogonal methodologies.