A photodynamic antibacterial spray-coating based on the host–guest immobilization of the photosensitizer methylene blue. Issue 33 (26th July 2019)

• Record Type: Journal Article
• Authors: Yao, Tian-tian; Wang, Jing; Xue, Yun-fan; Yu, Wei-jiang; Gao, Qiang; Ferreira, Lino; Ren, Ke-Feng; Ji, Jian
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 33(2019)
• Page Start: 5089
• Page End: 5095
• Publication Date: 2019-07-26
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb01069f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : An efficient photodynamic antibacterial spray-coating is developed with a very low MB density and high singlet oxygen quantum yield. Abstract : In the "post-antibiotic era", healthcare-associated infection has become a global problem that threatens public health and causes huge economic losses. The development of antibacterial coatings based on non-antibiotic strategies is particularly important as drug-resistant bacteria continue to evolve. Photodynamic coatings are a high potential method to treat bacteria, however, the aggregation of photosensitizers on the coating affects the photodynamic capacity seriously. Herein, a photodynamic coating is developed based on the host–guest interaction between β-cyclodextrin and the photosensitizer methylene blue (MB). The host–guest interaction avoids aggregation of MB and results in a high singlet oxygen quantum yield. Consequently, efficient photoantibacterial activity towards methicillin-resistant Staphylococcus aureus is achieved by the photodynamic coating with very low MB density (0.53 ± 0.06 μg cm −2 ).