Role of the peritrophic matrix in insect-pathogen interactions. (August 2019)

• Record Type: Journal Article
• Authors: Erlandson, Martin A.; Toprak, Umut; Hegedus, Dwayne D.
• Is Part Of: Journal of insect physiology. Volume 117(2019)
• Publication Date: 2019-08
• Subjects: Insects -- Physiology -- Periodicals; Insectes -- Physiologie -- Périodiques; Insects -- Physiology; Periodicals; 571.157
• DOI: 10.1016/j.jinsphys.2019.103894
• Languages: English
• ISSNs: 0022-1910

Abstract

Graphical abstract: Highlights: Evidence for the role of the insect PM as a barrier to pathogenic microorganisms is reviewed. Evolution of pathogen encoded enzymes and their potential mode of action in overcoming the PM is discussed. The role of the insect PM in sequestering pathogens and their associated toxins is discussed. Abstract: The peritrophic matrix (PM) is an acellular chitin and glycoprotein layer that lines the invertebrate midgut. The PM has long been considered a physical as well as a biochemical barrier, protecting the midgut epithelium from abrasive food particles, digestive enzymes and pathogens infectious per os . This short review will focus on the latter function, as a barrier to pathogens infectious per os. We focus on the evidence confirming the role of the PM as protective barrier against pathogenic microorganisms of insects, mainly bacteria and viruses, as well as the evolution of a variety of mechanisms used by pathogens to overcome the PM barrier.