Reconstitution of Organismal Liver Clock Function Requires Light. (September 2019)

• Record Type: Journal Article
• Authors: Miyake, Takahito; Doi, Masao
• Is Part Of: Trends in endocrinology and metabolism. Volume 30:Number 9(2019)
• Page Start: 569
• Page End: 571
• Publication Date: 2019-09
• Subjects: circadian -- light -- Bmal1 -- liver metabolism -- systemic signaling -- diurnal physiology -- autonomy; Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2019.07.017
• Languages: English
• ISSNs: 1043-2760

Abstract

Abstract : Recently Koronowski et al . ( Cell, 2019) showed that reconstitution of the liver circadian clock in otherwise genetically arrhythmic mice revives the daily program of the nicotinamide adenine dinucleotide salvage pathway and glycogenesis in vivo . This liver-autonomous metabolic cycling cannot be sustained under constant darkness, revealing the importance of the daily light cycle to restore liver function.