Water compatible molecularly imprinted polymer for controlled release of riboflavin as drug delivery system. (September 2019)

• Record Type: Journal Article
• Authors: Mokhtari, Payam; Ghaedi, Mehrorang
• Is Part Of: European polymer journal. Volume 118(2019)
• Page Start: 614
• Page End: 618
• Publication Date: 2019-09
• Subjects: Molecularly imprinted polymer -- Riboflavin -- Drug delivery -- Chitosan -- Controlled release; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2019.06.038
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlight: Water compatible molecularly imprinted biopolymer was synthesized in green and mild condition using Riboflavin as template. The prepared biopolymer has supreme ability in drug delivery systems. Higuchi model was used to describe the physical riboflavin release mechanism in MIP. Abstract: In this study, facile and green method for synthesis of imprinted material was introduced which subsequently applied for efficient delivery of Riboflavin (vitamin B2 ). Characterization of the prepared polymer was carried out by the Fourier Transform Infrared (FT-IR) spectroscopy and Scanning Electron Microscopy (SEM). The weight ratio of functional monomer to template over 5–20 W/W% was evaluated in order to find the best loading condition and subsequent release into synthetic biomimetic media namely simulated body fluid (SBF) and media including 1% NaCl solution, simulated gastric fluid (SGF) solution at pH 1.5 and the solution of 1% W/W Na2 SO4 . Under optimized condition, the highest value of released riboflavin was achieved at 1:20 ratio of riboflavin to polymer in NaCl (55.07%) media which providing that the body requirement about 5 days of this vitamin between minimum effective concentration (MEC) and maximum safe concentration (MSC) of Riboflavin in short release time (45 min). Moreover, the experimental data were fitted to Higuchi model in order to calculate Higuchi solubility constant.