High-speed atomic force microscopy. (August 2019)

• Record Type: Journal Article
• Authors: Ando, Toshio
• Is Part Of: Current opinion in chemical biology. Volume 51(2019)
• Page Start: 105
• Page End: 112
• Publication Date: 2019-08
• Subjects: Bioorganic chemistry -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Clinical biochemistry -- Periodicals; Biochemistry -- Periodicals; Chimie bio-organique -- Périodiques; Biologie -- Périodiques; 572.05
• DOI: 10.1016/j.cbpa.2019.05.010
• Languages: English
• ISSNs: 1367-5931

Abstract

Abstract : High-speed atomic force microscopy (HS-AFM) is a unique tool for molecular imaging. It can directly visualize protein molecules during their functional activity at high spatiotemporal resolution, without a marker being attached to the molecules. Molecular dynamics filmed with HS-AFM can provide mechanistic insights into the functional molecular processes that are hard to be attained with other approaches. In this mini review, I highlight some of recent relevant studies of proteins by HS-AFM imaging after brief descriptions of AFM and HS-AFM.