Keratoacanthoma centrifugum marginatum after photodynamic therapy with good response to oral retinoids and topical 5‐fluorouracil. Issue 4 (21st June 2019)

• Record Type: Journal Article
• Authors: Silva, Esmeralda; Estébanez, Andrea; Martín, Jose Maria; Monteagudo, Carlos; Montesinos, Encarnación
• Is Part Of: Dermatologic therapy. Volume 32:Issue 4(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-06-21
• Subjects: keratoacanthoma centrifugum marginatum -- oral retinoids -- topical 5‐fluorouracil; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/dth.12988
• Languages: English
• ISSNs: 1396-0296

Abstract

Abstract: Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA), characterized by progressive peripheral growth, and usually devoid of deep invasion. Different systemic (oral retinoids) or topical treatments have been reported, but there is not a well‐defined therapeutic protocol. We report the case of a KCM developing after photodynamic therapy (PDT) on the right leg of a 64‐year‐old woman. It was treated successfully with oral acitretin combined with topical 5‐Fluorouracil + salicylic acid for 5 months. This is the first case of KCM developing after PDT and successfully treated with oral retinoid combined with topical treatment.