GABAergic‐astrocyte signaling: A refinement of inhibitory brain networks. Issue 10 (30th May 2019)

• Record Type: Journal Article
• Authors: Mederos, Sara; Perea, Gertrudis
• Is Part Of: Glia. Volume 67:Issue 10(2019)
• Page Start: 1842
• Page End: 1851
• Publication Date: 2019-05-30
• Subjects: astrocyte -- excitation/inhibition balance -- GABAergic interneurons -- gliotransmission -- synaptic plasticity; Neuroglia -- Periodicals; Neurology -- Periodicals; 611.0188
• DOI: 10.1002/glia.23644
• Languages: English
• ISSNs: 0894-1491

Abstract

Abstract: Interneurons play a critical role in precise control of network operation. Indeed, higher brain capabilities such as working memory, cognitive flexibility, attention, or social interaction rely on the action of GABAergic interneurons. Evidence from excitatory neurons and synapses has revealed astrocytes as integral elements of synaptic transmission. However, GABAergic interneurons can also engage astrocyte signaling; therefore, it is tempting to speculate about different scenarios where, based on particular interneuron cell type, GABAergic‐astrocyte interplay would be involved in diverse outcomes of brain function. In this review, we will highlight current data supporting the existence of dynamic GABAergic‐astrocyte communication and its impact on the inhibitory‐regulated brain responses, bringing new perspectives on the ways astrocytes might contribute to efficient neuronal coding. Main points: Astrocytic responses heterogeneity to different interneuron cell types. GABAergic‐driven cognitive behaviors are regulated by interneuron‐astrocyte dynamic signaling.