Hierarchical Nanotube Self‐Assembly of DNA Minor Groove‐Binding Ligand DB921 via Alkali Halide Triggering. Issue 1 (14th August 2019)

• Record Type: Journal Article
• Authors: Mizuta, Ryo; Devos, Juliette M.; Narayanan, Theyencheri; Oliva, Mizar; Gray, Melissa; Webster, Jessica; Ling, Wai‐Li; Round, Adam; Munnur, Deeksha; Mossou, Estelle; Farahat, Abdelbasset; Boykin, David W.; Wilson, W. David; Neidle, Stephen; Schweins, Ralf; Rannou, Patrice; Haertlein, Michael; Forsyth, V. Trevor; Mitchell, Edward
• Other Names: Putaux Jean‐Luc guestEditor.; Forsyth Trevor guestEditor.; Ogawa Yu guestEditor.; Prévost Sylvain guestEditor.; Schweins Ralf guestEditor.
• Is Part Of: Macromolecular symposia. Volume 386:Issue 1(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-08-14
• Subjects: nanotubes -- self‐assembly -- small‐angle X‐ray scattering -- transmission electron microscopy; Macromolecules -- Congresses; Polymers -- Congresses; Polymerization -- Congresses; Macromolecules -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1002/masy.201800243
• Languages: English
• ISSNs: 1022-1360

Abstract

Abstract : A systematic study into a novel self‐assembling system is presented whereby the small molecule DB921 forms nearly monodisperse nanotubes upon addition of a suitable salt. Small‐angle X‐ray scattering and negative stain transmission electron microscopy are employed as the principal characterization methods to study both the fundamental assembly processes and reaction kinetics. The assembly is found to be hierarchical, culminating with helical winding of intermediate ribbon structures into nanotubes. The driving force for this process is likely the electrostatic interaction between DB921 and salt anions; this aspect can be used to control nanotube assembly and morphology.