Biomacromolecule‐Functionalized AIEgens for Advanced Biomedical Studies. Issue 32 (10th February 2019)

• Record Type: Journal Article
• Authors: Wu, Feng; Wu, Xia; Duan, Zhijuan; Huang, Yu; Lou, Xiaoding; Xia, Fan
• Is Part Of: Small. Volume 15:Issue 32(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-02-10
• Subjects: AIEgens -- biomacromolecules -- biomedical study -- functionalized methods -- theranostics; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201804839
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: The advances in bioinformatics and biomedicine have promoted the development of biomedical imaging and theranostic systems to respectively extend the endogenous biomarker imaging with high contrast and enhance the therapeutic effect with high efficiency. The emergence of biomacromolecule‐functionalized aggregation‐induced emitters (AIEgens), utilizing AIEgens, and biomacromolecules (nucleic acids, peptides, glycans, and lipids), displays specific targeting ability to cancer cell, improved biocompatibility, reduced toxicity, enhanced therapeutic effect, and so forth. This review summarizes the rational design of biomacromolecule‐functionalized AIEgens and their biomedical applications in recent ten years, including high‐resolution optical imaging of cell, tissue, and small animal model with low background; the biomarker detection for early diagnosis and prognosis; the delivery and monitoring of prodrugs; image‐guide photodynamic therapy and its combination with chemotherapy. Through illustrating their functional mechanisms and application, it is hoped that this review would open up a completely new train of research thought for attracted researchers in various fields. Abstract : The design principles and functionalized methods of biomacromolecule functionalized AIEgens are introduced herein. They include nucleic acid‐, peptide‐, glycan‐, and lipid‐functionalized AIEgens, which are highly desired for biomedical study, biotechnology, bioinformatics, and clinical science. Through illustrating their functional mechanisms and biological applications, it may be a guide for researchers from various fields.