Carbon Dots for In Vivo Bioimaging and Theranostics. Issue 32 (18th February 2019)

• Record Type: Journal Article
• Authors: Du, Jianjun; Xu, Ning; Fan, Jiangli; Sun, Wen; Peng, Xiaojun
• Is Part Of: Small. Volume 15:Issue 32(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-02-18
• Subjects: carbon dots -- diagnostics -- nanomedicine -- theranostics -- therapeutics; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201805087
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Carbon dots (CDs), a kind of carbon material discovered accidentally, exhibit unexpected advantages in fluorescence imaging/sensing such as photostability, biocompatibility, and low toxicity. For emerging theranostics, an interdiscipline created by integrating therapy and diagnostics, CDs are good candidates when they are combined with targeted chemo/gene/photodynamic/photothermal therapeutic moieties. Here, the development of CDs in nanomedicine is reviewed from their use as original imaging agents and/or drug carriers to multifunctional theranostic systems. Finally, the challenges and prospects of the next‐generation of CD‐based theranostics for clinical applications are also discussed. Abstract : Carbon dots (CDs) in nanomedicine are gradually developed from original imaging agents and/or drug carriers to smart multifunctional theranostic systems. In addition to having the common advantages of stability, biocompatibility, and low toxicity, CDs with special photothermal therapy/ photodynamic therapy capability are successfully exploited. This work addresses recent encouraging progress in the development of CD‐based multifunctional nanomedicinal agents in theranostics.