Protective effect of green tea catechin against urban fine dust particle-induced skin aging by regulation of NF-κB, AP-1, and MAPKs signaling pathways. (September 2019)

• Record Type: Journal Article
• Authors: Wang, Lei; Lee, WonWoo; Cui, Yong Ri; Ahn, Ginnae; Jeon, You-Jin
• Is Part Of: Environmental pollution. Volume 252(2019):Part B
• Page Start: 1318
• Page End: 1324
• Publication Date: 2019-09
• Subjects: (−)-Epigallocatechin gallate -- Fine dust particles -- HDFs -- NF-κB -- AP-1 -- MAPKs; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2019.06.029
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: The increase in ambient fine dust particles (FDP) due to urbanization and industrialization has been identified as a major contributor to air pollution. It has become a serious issue that threatens human health because it causes respiratory diseases and skin aging. In the present study, the protective effect of the green tea catechin, (−)-epigallocatechin gallate (EGCG), against FDP (ERM-CZ100)-stimulated skin aging in human dermal fibroblasts (HDFs) was investigated. The results demonstrate that EGCG significantly and dose-dependently scavenged intracellular reactive oxygen species (ROS) in and increased the viability of FDP-stimulated HDFs. In addition, EGCG dose-dependently recovered collagen synthesis and inhibited intracellular elastase and collagenase activities. Moreover, EGCG decreased the expression of human matrix metalloproteinases (MMPs) via regulation of nuclear factor kappa B (NF-κB), activator protein 1 (AP-1), and mitogen-activated protein kinases (MAPKs) signaling pathways in FDP-stimulated HDFs. This study suggests that EGCG is a potential anti-aging candidate that can be used for FDP-induced skin aging as a therapeutic agent itself or as an ingredient in pharmaceutical and cosmeceutical products. Graphical abstract: Image 10138 Highlights : Fine dust particles (FDP) cause skin aging. The green tea catechin, EGCG against FDP-stimulated skin aging in HDFs. EGCG scavenges intracellular ROS and inhibits MMPs expression in FDP-stimulated HDFs. EGCG regulating NF-κB, AP-1, and MAPKs signaling pathways in FDP-stimulated HDFs.