Patterns of Local and Systemic Cytokines in Bacterial Meningitis and its Relation with Severity and Long-Term Sequelae. Issue 10 (January 2015)

• Record Type: Journal Article
• Authors: Perdomo-Celis, Federico; Torres, Miguel A.; Ostos, Henry; Gutierrez-Achury, Javier; Molano, Victor; Durán, Luis F.; Gonzalez, Guillermo; Narváez, Carlos F.
• Is Part Of: Biomarker insights. Volume 2015:Issue 10(2015)
• Publication Date: 2015-01
• Subjects: bacterial meningitis -- Streptococcus pneumoniae -- sequelae -- biomarkers -- cerebrospinal fluid -- cytokines; Biochemical markers -- Periodicals; 572.43
• DOI: 10.4137/BMI.S35005
• Languages: English
• ISSNs: 1177-2719

Abstract

Bacterial meningitis (BM) is a pyogenic infection present in the subarachnoid space, potentially fatal and frequently associated with neurological sequelae. During BM, cytokines (CTs) are locally produced. We sought to determine the CTs' clinical role as disease severity predictors in adults, which is not completely clear. Using a bead-based flow cytometric assay, levels of six CTs were determined in cerebrospinal fluid (CSF) and plasma from 18 adult BM patients and 19 uninfected controls. Long-term neurological sequelae were evaluated using the Glasgow Outcome Scale (GOS). All evaluated CTs were higher in CSF than in plasma, and the levels of CSF interleukin (IL)-6, IL-8, IL-10, IL-1β, and tumor necrosis factor-α and plasma IL-10 and IL-12p70 were significantly higher in patients with severe sepsis than with sepsis, suggesting an association with clinical severity. There was a strong negative correlation between CSF IL-6 and plasma IL-12p70 with GOS score, supporting the possible role of these CTs in the development of neurological long-term sequelae. These findings could be helpful to identify candidates to receive neuroprotective treatments and early physiotherapy schemes.