Urinary Neutrophil Gelatinase-Associated Lipocalin to Monitor Lupus Nephritis Disease Activity. Issue 10 (January 2015)

• Record Type: Journal Article
• Authors: Susianti, Hani; Wijaya, Jullyanny W.; Rastini, Ati; Handono, Kusworini; Gunawan, Atma; Kalim, Handono
• Is Part Of: Biomarker insights. Volume 2015:Issue 10(2015)
• Publication Date: 2015-01
• Subjects: lupus nephritis -- uNGAL -- uTGF-β1 -- disease activity; Biochemical markers -- Periodicals; 572.43
• DOI: 10.4137/BMI.S27625
• Languages: English
• ISSNs: 1177-2719

Abstract

Background: This study was conducted to determine whether there is an association between urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary transforming growth factor-β1 (uTGF-β1) with lupus nephritis (LN) disease activity. Methods: Urine samples from 18 LN patients were collected every month for six months then examined for uNGAL, uTGF-β1, and renal domain Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score. Results: The uNGAL levels were significantly different between active and inactive LN (P < 0.05). uTGF-β1 levels were not different between active and inactive LN (P > 0.05). There was a significant correlation between uNGAL levels and renal domain SLEDAI score (r= 0.417, P < 0.05). There was no correlation between uTGF-β1 levels and renal domain SLEDAI score (r = 0.031, P > 0.05). Conclusion: uNGAL is better than uTGF-β1 for differentiation of active and inactive LN. uNGAL can be considered as a biomarker to monitor LN disease activity.