Catalyst-free Petasis-type reaction: Three-component decarboxylative coupling of boronic acids with proline and salicylaldehyde for the synthesis of alkylaminophenols. Issue 11 (14th March 2018)

• Record Type: Journal Article
• Authors: Kaboudin, Babak; Zangooei, Ali; Kazemi, Foad; Yokomatsu, Tsutomu
• Is Part Of: Tetrahedron letters. Volume 59:Issue 11(2018)
• Page Start: 1046
• Page End: 1049
• Publication Date: 2018-03-14
• Subjects: Boronic acid -- Salicylaldehyde -- Proline -- Coupling -- Petasis-type reaction; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.02.003
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A simple and practical method for the synthesis of alkylaminophenols. Three-component reaction of proline with arylboronic acid and salicylaldehyde. Petasis-type reaction. Catalyst-free reaction, mild reaction conditions, and high selectivity. Abstract: A simple method is reported for the synthesis of alkylaminophenols in moderate to good yields via a three-component, catalyst-free decarboxylative coupling of proline with salicylaldehyde and boronic acids.