Direct arylation of tertiary amines via aryne intermediates using diaryliodonium salts. Issue 18 (2nd May 2018)

• Record Type: Journal Article
• Authors: Zhang, Zhiang; Wu, Xunshen; Han, Jianwei; Wu, Wenjun; Wang, Limin
• Is Part Of: Tetrahedron letters. Volume 59:Issue 18(2018)
• Page Start: 1737
• Page End: 1741
• Publication Date: 2018-05-02
• Subjects: Diaryliodonium salts -- Benzyne -- Arylation -- Aromatic tertiary amines; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.03.067
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A synthetic method of N -arylation of tertiary amines via benzynes with diaryliodonium salts was developed. The desire aromatic tertiary amines were synthesized in good yields of 55–91%. Diaryliodonium salts was used as the precursors of benzynes. Abstract: With a strategy by using diaryliodonium salts as the precursors of benzynes, direct N -arylation of tertiary amines with diaryliodonium salts was reported. Thus, the desired aromatic tertiary amines with a wide range of substituents were synthesized in moderate to excellent yields of 55–91%.