Indole diterpenoids from the endophytic fungus Drechmeria sp. as natural antimicrobial agents. (April 2018)

• Record Type: Journal Article
• Authors: Zhao, Jian-Chao; Wang, Ya-Li; Zhang, Tian-Yuan; Chen, Zhong-Jian; Yang, Tian-Mei; Wu, Ying-Ying; Sun, Cheng-Peng; Ma, Xiao-Chi; Zhang, Yi-Xuan
• Is Part Of: Phytochemistry. Volume 148(2018)
• Page Start: 21
• Page End: 28
• Publication Date: 2018-04
• Subjects: Drechmeria sp. -- Indole diterpenoids -- Theoretical calculation -- Antimicrobial activity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2018.01.010
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: A fungal strain, Drechmeria sp., was isolated from the root of Panax notoginseng . Totally, seven new indole diterpenoids, drechmerins A-G (1 –7 ), were isolated from the fermentation broth of Drechmeria sp. together with four known analogues (8 –11 ). Their structures were determined on the basis of 1D and 2D NMR and electronic circular dichroism (ECD) spectroscopic analyses as well as theoretical calculations. All the isolated compounds were evaluated for their antimicrobial activities against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin B (2 ) displayed antimicrobial activity against C. albicans with an MIC value of 12.5 μg/mL. Molecular docking was used to investigate interactions of peptide deformylase with compounds1–3, 5–7, 9, and10 . Graphical abstract: Highlights: Seven new indole diterpenoids1–7 were isolated from the fermentation broth of Haptocillium sp. Compounds1–11 were assayed for their antimicrobial effects. Compound2 displayed significant antimicrobial effect against C. albicans. Molecular docking revealed interactions of compounds with peptide deformylase.