The mitochondrial tRNAGln T4353C mutation may not be associated with essential hypertension in Han Chinese population. (2nd September 2016)

• Record Type: Journal Article
• Authors: Meng, Xing; Pei, Hui; Lan, Chao
• Is Part Of: Mitochondrial DNA. Volume 27:Number 5(2016)
• Page Start: 3311
• Page End: 3312
• Publication Date: 2016-09-02
• Subjects: Haplogroup -- mitochondrial tRNAGln -- T4353C mutation
• DOI: 10.3109/19401736.2015.1018199
• Languages: English
• ISSNs: 2380-2359

Abstract

Abstract: We reported here the possible role of a mitochondrial tRNA mutation: T4353C in clinical expression of essential hypertension in Chinese population. The human mammalian mitochondrial tRNA database was used to analyze the conservation index of this mutation between different species. Moreover, phylogenetic analysis showed that the T4353C mutation belonged to human mitochondrial haplogroup HV, a West Eurasian haplogroup found throughout Western Asia and Eastern European but was infrequent in China. In addition, structural prediction of the T4353C mutation indicated that this transition did not alter the secondary structure of tRNA Gln . Together, our data indicated that the T4353C mutation occurred infrequent and may not be associated with essential hypertension in Han Chinese population.