Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations. Issue 9 (27th July 2016)

• Record Type: Journal Article
• Authors: Yamada, Ai; Moritake, Hiroshi; Kinoshita, Mariko; Sawa, Daisuke; Kamimura, Sachiyo; Iwamoto, Shotaro; Yamashita, Yuka; Inagaki, Jiro; Takahashi, Takahide; Shimada, Akira; Obara, Megumi; Nunoi, Hiroyuki
• Is Part Of: Pediatrics international. Volume 58:Issue 9(2016)
• Page Start: 905
• Page End: 908
• Publication Date: 2016-07-27
• Subjects: acute myeloid leukemia -- allelic burden -- FLT3‐internal tandem duplication -- inv(16) -- KIT; Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.13010
• Languages: English
• ISSNs: 1328-8067

Abstract

Abstract: Inversion of chromosome 16 [inv(16)] has a good prognosis in acute myeloid leukemia (AML), but additional genetic aberrations influence the outcome. We herein describe the case of a 15‐year‐old Japanese boy with inv(16) harboring a low‐allelic burden internal tandem duplication of FLT3 ( FLT3 ‐ITD) and KIT mutations. Conventional chemotherapy eradicated a clone with a low‐allelic burden FLT3 ‐ITD mutation, although another clone with a KIT mutation occurred 17 months later. Further investigation is necessary to identify AML with inv(16) conferring poor prognosis, to facilitate appropriate treatment with additional drugs, such as dasatinib or gemtuzumab ozogamicin.