Long‐term outcomes of patients with type 2 diabetes attending a multidisciplinary diabetes kidney disease clinic: 在多学科糖尿病肾病诊所就诊的2型糖尿病患者的长期预后. Issue 7 (28th December 2017)

• Record Type: Journal Article
• Authors: Low, Serena; Lim, Su Chi; Wang, Jiexun; Yeoh, Lee Ying; Liu, Yan Lun; Lim, Eng Kuang; Shao, Yan Li; Chui, Winnie; Fun, Sharon; Chua, Chin Lian; Subramaniam, Tavintharan; Sum, Chee Fang
• Is Part Of: Journal of diabetes. Volume 10:Issue 7(2018)
• Page Start: 572
• Page End: 580
• Publication Date: 2017-12-28
• Subjects: chronic kidney disease -- diabetes mellitus -- glomerular filtration rate; 慢性肾脏疾病 -- 糖尿病 -- 肾小球滤过率; Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12626
• Languages: English
• ISSNs: 1753-0393

Abstract

Abstract: Background: The best model of care to retard diabetic kidney disease (DKD) in the clinic is underexplored. In this study we investigated the long‐term renal outcomes of a joint endocrinologist–nephrologist clinic. Methods: The present study was a nested case‐control study derived from a cohort of patients with type 2 diabetes mellitus (T2DM) seen prospectively at a secondary care diabetes center (DC). Cases ("DKD clinic group") were patients seen at the CKD clinic after being referred by physicians in DCs for management of DKD. Controls ("non‐DKD clinic group") were patients from the same DC (i.e. same source population) with the same inclusion criteria of Stages 3–4 chronic kidney disease (CKD) at baseline but not seen at the DKD clinic. The outcome was Stage 5 CKD, defined as an estimated glomerular filtration rate <15 mL/min per 1.73 m 2 . Results: During the median follow‐up period of 3.0 years (interquartile range 1.2–5.1 years), 240 patients (28.7%) reached Stage 5 CKD, with 45.8% and 54.2% of those reaching Stage 5 CKD in the DKD and non‐DKD clinic groups, respectively. Multivariable Cox regression revealed that the DKD clinic group had a lower risk of progressing to Stage 5 CKD (hazard ratio 0.55; 95% confidence interval 0.36–0.83; P = 0.004) compared with the non‐DKD clinic group. Conclusions: Multidisciplinary endocrinology and nephrology care in the DKD clinic is associated with a lower risk of end‐stage renal disease. These findings may inform future management strategies targeted at patients with T2DM and CKD, especially with regard to joint specialist management involving endocrinologists and nephrologists. Abstract : Highlights The best model of care to retard diabetes kidney disease (DKD) in the clinic is currently underexplored. Multidisciplinary endocrinology and nephrology care in the DKD clinic is associated with a lower risk of end‐stage renal disease.