A water-soluble fluorescence chemosensor for the sequential detection of Zn2+ and pyrophosphate in living cells and zebrafish. (May 2018)

• Record Type: Journal Article
• Authors: Kang, Ji Hye; Han, Jiyeon; Lee, Hyojin; Lim, Mi Hee; Kim, Ki-Tae; Kim, Cheal
• Is Part Of: Dyes and pigments. Volume 152(2018)
• Page Start: 131
• Page End: 138
• Publication Date: 2018-05
• Subjects: Fluorescent chemosensor -- Zinc ion -- Pyrophosphate -- Cell imaging -- Zebrafish -- Theoretical calculations; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2018.01.039
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: A new simple aminohydantoin-based fluorescent chemosensor1 was designed for sequential detection of Zn 2+ and pyrophosphate in a near-perfect aqueous solution.1 exhibited significant fluorescence intensity in the presence of Zn 2+, and the resulting1 -Zn 2+ complex showed subsequently the fluorescent quenching with pyrophosphate. The detection limit (0.32 μM) of1 for Zn 2+ was far lower than the guideline of World Health Organization in drinking water.1 was used to determine Zn 2+ concentration in various water samples. In addition, chemosensor1 could be applied to sequentially detect Zn 2+ and pyrophosphate in living cells and zebrafish. The sensing mechanism of Zn 2+ by1 was proposed to be an intramolecular charge transfer with theoretical calculations. Graphical abstract: Highlights: A water-soluble fluorescent chemosensor1 was designed for sequential detection of Zn 2+ and pyrophosphate (PPi). Detection limit (0.32 μM) of1 for Zn 2+ was much lower than the WHO guideline (76 μM) for Zn 2+ in drinking water. Sensor1 could be applied to sequentially detect both Zn 2+ and PPi in living cells and zebrafish. Sensing mechanism of1 toward Zn 2+ was explained by theoretical calculations.