Prognostic value of tissue necrosis, hypoxia-related markers and correlation with HPV status in head and neck cancer patients treated with bio- or chemo-radiotherapy. Issue 1 (January 2018)

• Record Type: Journal Article
• Authors: Ou, Dan; Garberis, Ingrid; Adam, Julien; Blanchard, Pierre; Nguyen, France; Levy, Antonin; Casiraghi, Odile; Gorphe, Philippe; Breuskin, Ingrid; Janot, François; Temam, Stephane; Scoazec, Jean-Yves; Deutsch, Eric; Tao, Yungan
• Is Part Of: Radiotherapy and oncology. Volume 126:Issue 1(2018)
• Page Start: 116
• Page End: 124
• Publication Date: 2018-01
• Subjects: Head-and-neck squamous cell carcinoma -- CD34 -- CA-IX -- Necrosis -- Human papillomavirus; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2017.10.007
• Languages: English
• ISSNs: 0167-8140

Abstract

Abstract: Background and purpose: The aim of the present study was to investigate the role of three hypoxia-related biomarkers in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with concurrent chemoradiotherapy (3-weekly cisplatin) or bioradiotherapy (weekly cetuximab). Material and methods: In tumor tissue material from 100 patients with known HPV status, we evaluated the extent of tumor necrosis, the expression level of CA-IX and the microvascular density (MVD) measured as the density of CD34+ vascular structures. The correlations between biomarker expressions and clinicopathological characteristics and treatment outcomes were analyzed. Results: We found a significant correlation of MVD with UICC stage ( p = 0.02) and T classification ( p = 0.05), of CA-IX with UICC stage ( p = 0.03) and N classification ( p = 0.04) and a significant inverse correlation of MVD with CA-IX expression ( r = − 0.22, p = 0.03). Multivariate analysis showed that low MVD combined with high CA IX-expression was a significant independent prognostic factor for worse loco-regional control (HR = 2.6, 95%CI 1.1–5.0, p = 0.02) in the whole population but not in the p16+ subgroup. Patients treated with CRT had a better LRC than those with BRT independent of MVD or CA-IX expression. Conclusions: The combination of MVD and CA-IX expression might give additional prognostic information in HNSCC patients with known HPV status.