Bioactive Glasses: Sprouting Angiogenesis in Tissue Engineering. Issue 4 (April 2018)

• Record Type: Journal Article
• Authors: Kargozar, Saeid; Baino, Francesco; Hamzehlou, Sepideh; Hill, Robert G.; Mozafari, Masoud
• Is Part Of: Trends in biotechnology. Volume 36:Issue 4(2018)
• Page Start: 430
• Page End: 444
• Publication Date: 2018-04
• Subjects: Biotechnology -- Periodicals; Biochemical engineering -- Periodicals; Genetic engineering -- Periodicals; Industrial microbiology -- Periodicals; 660.605
• DOI: 10.1016/j.tibtech.2017.12.003
• Languages: English
• ISSNs: 0167-7799

Abstract

Abstract : The biggest strategic challenge for tissue engineering is the development of efficient vascularized networks in engineered tissues and organs. Bioactive glasses (BGs) are potent biomaterials for inducing angiogenesis in hard and soft tissue engineering applications. Because tissue-healing processes strongly depend on angiogenesis, recent interest in BGs has increased dramatically. BGs with improved angiogenetic properties can be developed by adding a range of metallic ions (e.g., Cu 2+, Co 2+ ) into their structure, but further development of BGs with improved angiogenic activity is required, and many crucial questions remain to be answered. We introduce here the salient features, the hurdles that must be overcome, and the hopes and constraints for the development of this approach. Highlights: The most successful tissue engineering strategies rely on the formation of vascular networks in newly developed tissues and organs to supply nutrients and oxygen. A series of elements can be incorporated into the structure of BGs that induce specific characteristics for tissue engineering applications. Newly developed BGs are able to promote angiogenic activities in hard and soft tissue engineering applications through the release of specific ions. This class of biomaterials offers new suggestions for overcoming the challenges associated with neovascularization within engineered tissue constructs.