Biocompatible nanocomposite of carboxymethyl cellulose and functionalized carbon–norfloxacin intercalated layered double hydroxides. (15th April 2018)

• Record Type: Journal Article
• Authors: Allou, N'guadi Blaise; Yadav, Archana; Pal, Mintu; Goswamee, Rajib Lochan
• Is Part Of: Carbohydrate polymers. Volume 186(2018)
• Page Start: 282
• Page End: 289
• Publication Date: 2018-04-15
• Subjects: Layered double hydroxides -- Sodium carboxymethyl cellulose -- Functionalized carbon -- Citric acid cross–linking -- Norfloxacin -- Controlled release; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2018.01.066
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: Norfloxacin was intercalated between LDH over the surface of activated carbon. Carboxymethyl cellulose cross-linked citric acid to protect LDH-Drug composite. In vitro drug release showed controlled and slow release for the hybrid composite. Abstract: In recent years, the development of systems with progressive drug release properties, which is an effective technique for the use of drugs, has aroused great interest in the field of controlled release formulations. In this work, hybrid materials containing citric acid cross–linked carboxymethyl cellulose (CMC) and norfloxacin (NOR) intercalated layered double hydroxide (LDH) deposited over the surface of functionalized carbon (AC) were prepared. The synthesized CMC@AC–LDHNOR nanohybrids were characterized using different techniques and in vitro NOR release behaviors were investigated in phosphate buffer saline, pH 7.4 at 37 °C. On the basis of the release profiles, it was found that NOR release was delayed when it was intercalated in AC–LDH which in presence of modified CMC decreases further. The nanohybrids indicated enhancement of antibacterial activity against gram–negative and gram–positive bacteria. The MTT assay showed their non–toxic behavior against ovarian normal epithelial and cancer cells, suggesting their potential use as drug carriers.