A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation. Issue 8 (August 2016)

• Record Type: Journal Article
• Authors: Bhandari, Apoorva; Radhu, Natasha; Farzan, Faranak; Mulsant, Benoit H.; Rajji, Tarek K.; Daskalakis, Zafiris J.; Blumberger, Daniel M.
• Is Part Of: Clinical neurophysiology. Volume 127:Issue 8(2016:Aug.)
• Page Start: 2834
• Page End: 2845
• Publication Date: 2016-08
• Subjects: TMS transcranial magnetic stimulation -- GABA gamma-aminobutyric acid -- RMT resting motor threshold -- SICI short-interval cortical inhibition -- SAI short-latency afferent inhibition -- CSP cortical silent period -- ICF intracortical facilitation -- PAS paired associative stimulation -- LTP long-term potentiation -- LTD long-term depression -- NMDA N-methyl-d-aspartate -- EMG electromyography -- ISI interstimulus interval -- CI confidence interval -- SD standard deviation -- CNS central nervous system -- PNS peripheral nervous system; Aging -- Transcranial magnetic stimulation -- Motor cortex -- Cortical plasticity -- Cortical excitability -- Gamma-aminobutyric acid; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2016.05.363
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: TMS measures of motor cortical excitation, inhibition and plasticity were assessed in young vs older adults. Age-related motor cortical hypo-excitability and a trending decrease in LTP-like plasticity observed. Older adults showed deficits in sensorimotor integration in comparison to young adults. Abstract: Objective: Transcranial magnetic stimulation (TMS) is a non-invasive tool used for studying cortical excitability and plasticity in the human brain. This review aims to quantitatively synthesize the literature on age-related differences in cortical excitability and plasticity, examined by TMS. Methods: A literature search was conducted using MEDLINE, Embase, and PsycINFO from 1980 to December 2015. We extracted studies with healthy old (50–89 years) versus young (16–49 years) individuals that utilized the following TMS measures: resting motor threshold (RMT), short-interval cortical inhibition (SICI), short-latency afferent inhibition (SAI), cortical silent period (CSP), intracortical facilitation (ICF), and paired associative stimulation (PAS). Results: We found a significant increase in RMT ( g = 0.414, 95% confidence interval (CI) [0.284, 0.544], p < 0.001), a significant decrease in SAI ( g = 0.778, 95% CI [0.478, 1.078], p < 0.001), and a trending decrease in LTP-like plasticity ( g = −0.528, 95% CI [−1.157, 0.100] p < 0.1) with age. Conclusions: Our findings suggest an age-dependent reduction in cortical excitability and sensorimotor integration within the human motor cortex. Significance: Alterations in the ability to regulate cortical excitability, sensorimotor integration and plasticity may underlie several age-related motor deficits.