Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni–Au core–shell nanowires. (14th December 2016)

• Record Type: Journal Article
• Authors: Hopkins, Xiaoping; Gill, Waqas Amin; Kringel, Rosemarie; Wang, Guankui; Hass, Jamie; Acharya, Suresh; Park, Jungrae; Jeon, In Tak; An, Boo Hyun; Lee, Ji Sung; Ryu, Jong Eun; Hill, Rod; McIlroy, David; Kim, Young Keun; Choi, Daniel S
• Is Part Of: Nanotechnology. Volume 28:Number 3(2017)
• Publication Date: 2016-12-14
• Subjects: RF-mediated thermotherapy -- magnetic core–shell nanowire -- RF radiation -- cancer; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/1361-6528/28/3/03LT01
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)–gold (Au) core–shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni–Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.