Impact of prenatal diagnosis of complex congenital heart disease on neonatal and infant morbidity and mortality. (27th September 2018)

• Record Type: Journal Article
• Authors: Chakraborty, Abhishek; Gorla, Sudheer R.; Swaminathan, Sethuraman
• Is Part Of: Prenatal diagnosis. Volume 38:Number 12(2018)
• Page Start: 958
• Page End: 963
• Publication Date: 2018-09-27
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.5351
• Languages: English
• ISSNs: 0197-3851

Abstract

Abstract: Objectives: The objective of this study was to analyze the benefits associated with prenatal diagnosis of complex congenital heart disease (CHD) on preoperative morbidity, 30‐day and 1‐year mortality in this population. Method: This was a retrospective review of patients with complex CHD born at our tertiary care center over a 10‐year period. Date analysis using Student t test and chi‐square test. Results: The overall rate of prenatal detection of complex CHD was 68.1%. A steady increase in the number of complex CHD diagnosed prenatally was noted during the study period. The prenatal diagnosis of complex CHD was associated with significant reduction in the incidence of the following preoperative parameters: antibiotic use, mechanical ventilation, inotropic support, hepatic and renal dysfunction, and acidosis. These beneficial effects were more significant in ductal‐dependent cardiac anomalies. However, there were no neonatal and infant survival benefits in association with prenatal diagnosis. Conclusion: Prenatal diagnosis of complex CHD leads to improved preoperative morbidity, especially in patients with ductal‐dependent cardiac anomalies. No survival benefits were noted with prenatal diagnosis of complex CHD. Abstract : What's already known about this topic? Complex congenital heart disease is associated with increased morbidity and mortality in infancy. The rate of prenatal diagnosis of heart defects has been improving over the past few decades. What does this study add? Prenatal diagnosis of complex congenital heart disease is associated with improved preoperative clinical and biochemical parameters. These benefits were mostly observed in neonates with ductal‐dependent heart defects.