Monocyte function in patients with myelodysplastic syndrome. Issue 3 (14th April 2018)

• Record Type: Journal Article
• Authors: Pollyea, Daniel A.; Hedin, Brenna R.; O'Connor, Brian P.; Alper, Scott
• Other Names: Ivashkiv Lionel guestEditor.; Li Liwu guestEditor.; Hu Xiaoyu guestEditor.
• Is Part Of: Journal of leukocyte biology. Volume 104:Issue 3(2018)
• Page Start: 641
• Page End: 647
• Publication Date: 2018-04-14
• Subjects: human leukocyte antigen–antigen D related -- LPS -- myelodysplastic syndrome -- PBMC -- phagocytosis; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.5AB1017-419RR
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Myelodysplastic syndrome (MDS) is a malignant hematopoietic stem cell disorder that frequently evolves into acute myeloid leukemia (AML). Patients with MDS are prone to infectious complications, in part due to the presence of severe neutropenia and/or neutrophil dysfunction. However, not all patients with neutropenia become infected, suggesting that other immune cells may compensate in these patients. Monocytes are also integral to immunologic defense; however, much less is known about monocyte function in patients with MDS. In the current study, we monitor the composition of peripheral blood monocytes and several aspects of monocyte function in MDS patients, including HLA‐DR expression, LPS‐induced inflammatory cytokine production, and phagocytosis. We find that monocytes from MDS patients exhibit relatively normal innate immune functions compared to monocytes from healthy control subjects. We also find that HLA‐DR expression is moderately increased in monocytes from MDS patients. These results suggest that monocytes could compensate for other immune deficits in MDS patients to help fight infection. We also find that the range of immune functions in monocytes from MDS patients correlates with several key clinical parameters, including blast cell count, monocyte count, and revised International Prognostic Scoring System score, suggesting that disease severity impacts monocyte function in MDS patients. Abstract : Monocytes from patients with Myelodysplastic Syndrome exhibit relatively normal immune function and could contribute to infection control in these patients.