Facile fabrication of hyaluronated starch nanogels for efficient docetaxel delivery. (July 2019)

• Record Type: Journal Article
• Authors: Yu, Hyeong Sup; Koo, Mijin; Choi, Sung-Wook; Na, Kun; Oh, Kyung Taek; Youn, Yu Seok; Lee, Eun Seong
• Is Part Of: Journal of bioactive and compatible polymers. Volume 34:Number 4/5(2019:Jul.)
• Page Start: 321
• Page End: 330
• Publication Date: 2019-07
• Subjects: Hyaluronated starch nanogels -- hyaluronidase -- docetaxel release -- tumor targeting -- CD44 receptor; Biomedical materials -- Periodicals; Polymers in medicine -- Periodicals; Polymers -- Periodicals; 547.7
• DOI: 10.1177/0883911519876067
• Languages: English
• ISSNs: 0883-9115

Abstract

In this study, we designed and synthesized polysaccharidic nanogels comprising starch cross-linked with hyaluronic acid. These hyaluronated starch nanogels were prepared by cross-linking primary hydroxyl groups in polysaccharides (starch and hyaluronic acid) and epoxide groups in 1, 4-butanediol diglycidyl ether (used as a cross-linking agent). The nanogels take advantage of hyaluronic acid as a specific ligand for CD44 receptors overexpressed on tumors and the hyaluronic acid/starch core as a compartment for the encapsulation of docetaxel (as model antitumor drug). Here, hyaluronic acid can be enzymatically degraded by tumor cell–specific enzyme (e.g. hyaluronidase-1), which could significantly accelerate docetaxel release from the nanogels. Our experimental results demonstrate that the nanogels promote the release of docetaxel content in the presence of hyaluronidase-1 enzyme. As a result, the nanogels selectively inhibited MCF-7 (with CD44 receptor and hyaluronidase-1 enzyme) tumor cell growth in vitro, suggesting their therapeutic potential for efficient tumor ablation.