ANGIOID STREAKS: A Comprehensive Review From Pathophysiology to Treatment. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Chatziralli, Irini; Saitakis, George; Dimitriou, Eleni; Chatzirallis, Alexandros; Stoungioti, Sofia; Theodossiadis, George; Theodossiadis, Panagiotis
• Is Part Of: Retina. Volume 39:Issue 1(2019)
• Publication Date: 2019-01
• Subjects: angioid streaks -- pathophysiology -- imaging -- treatment -- photodynamic therapy -- ranibizumab -- aflibercept; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000002327
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To stratify the literature on angioid streaks, from pathophysiology to treatment. Methods: Review of the current literature. Results: Angioid streaks are crack-like dehiscences of Bruch membrane, which may coexist with systemic diseases, such as pseudoxanthoma elasticum, Paget disease, Ehlers–Danlos syndrome, hemoglobinopathies, or other diseases of the collagen. Various diagnostic methods, including infrared and red-free retinography, autofluorescence, optical coherence tomography, fluorescein angiography, and indocyanine green angiography, are useful to diagnose, evaluate, and monitor angioid streaks. Choroidal neovascularization consists of a major complication of angioid streaks leading to visual impairment. Therefore, observation could not be a treatment option. Photodynamic treatment or anti–vascular endothelial growth factor agents have been used for the treatment of angioid streaks, offering promising but short-term results. Currently, the available treatment may limit the disease, but not permanently inactivate it. Conclusion: This review discusses the epidemiology, pathophysiology, diagnosis, and treatment of angioid streaks, presenting the existing literature on this topic. Abstract : This review makes an update of the literature regarding angioid streaks, giving emphasis to epidemiology, pathophysiology, histology, clinical characteristics, imaging, and potential treatment modalities.