Retrospective evaluation of statin prescription in the elderly. Issue 12 (5th December 2018)

• Record Type: Journal Article
• Authors: Chee, Wee Jie; Abdullahi, Huda; Chan, Yolanda; Rattle, Amelia; Snedden, Stephanie; Junckerstorff, Ralph
• Is Part Of: Internal medicine journal. Volume 48:Issue 12(2018)
• Page Start: 1463
• Page End: 1471
• Publication Date: 2018-12-05
• Subjects: statin -- elderly -- geriatrics -- drug interactions -- adverse drug reactions -- prescription; Medicine -- Periodicals; 616
• DOI: 10.1111/imj.13996
• Languages: English
• ISSNs: 1444-0903

Abstract

Abstract: Background: Statins are one of the most commonly prescribed medications in Australia. Although the cardioprotective effects of statins are well documented, questions remain regarding their risk–benefit profile in elderly adults, especially those with limited life expectancies. Aim: To describe the prevalence and pattern of statin use in elderly patients admitted to a General Medicine Unit. Methods: We retrospectively reviewed medical records of patients aged ≥80 years who were admitted to the General Medical Unit at Monash Medical Centre between 1 January 2015 and 30 June 2015. Patients receiving statin therapy prior to admission were identified and included. Data including patient demographics, indication for statin, comorbidities, co‐prescription of interacting medications, presence of muscle‐related toxicity and any change to statin prescription were collected and described. Results: Of 852 patients admitted to hospital, 359 (42%) were taking statins prior to admission. Statins were used for the secondary prevention of cardiovascular disease in 63% of patients and for primary prevention in 24%. Most patients were taking high‐ (16%) or medium‐intensity statins (78%); 46% of patients were co‐prescribed medications with the potential to increase the risk of statin toxicity. Statins were discontinued in 16% of patients; however, the majority of patients had no change to their statin prescription. Muscle‐related toxicity was documented in 4% of patients. Conclusion: Statin use and the co‐prescription of potentially interacting medications are common in elderly adults admitted to hospital. Statin prescription in elderly patients with multiple comorbidities is rarely reviewed unless directly relevant to their admission diagnosis.