Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics. Issue 3 (17th April 2018)

• Record Type: Journal Article
• Authors: Balint, Bettina; Wiethoff, Sarah; Martino, Davide; del Gamba, Claudia; Latorre, Anna; Ganos, Christos; Houlden, Henry; Bhatia, Kailash P.
• Is Part Of: Movement disorders clinical practice. Volume 5:Issue 3(2018)
• Page Start: 317
• Page End: 320
• Publication Date: 2018-04-17
• Subjects: paroxysmal kinesigenic dyskinesia (PKD) -- tics -- PRRT2; Movement Disorders; Movement disorders -- Periodicals; Movement disorders; Periodicals; Periodicals; 616
• DOI: 10.1002/mdc3.12615
• Languages: English
• ISSNs: 2330-1619

Abstract

Abstract: Background: Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterised by brief attacks of chorea, dystonia, or mixed forms precipitated by sudden movement. Methods: Observational study with a cohort of 14 PKD patients and genetic testing for PRRT2 mutations. Results: In a series of 14 PKD patients seen in our clinic at the National Hospital of Neurology, Queen Square, from 2012–2017, we noted tics in 11 patients (79%), which stand in stark contrast to the estimated lifetime prevalence of tics estimated to reach 1%. Conclusions: The two reasons to point out this possible association are the clinical implications and the potential opportunity of a better understanding of shared pathophysiological mechanisms of neuronal hyperexcitability. Abstract : View Supplementary Video View Supplementary Video