Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer's disease. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Karim, Roksana; Koc, Melissa; Rettberg, Jamaica R.; Hodis, Howard N.; Henderson, Victor W.; St. John, Jan A.; Allayee, Hooman; Brinton, Roberta D.; Mack, Wendy J.
• Is Part Of: Menopause. Volume 26:Issue 1(2019)
• Publication Date: 2019-01
• Subjects: Alzheimer disease -- Biomarker -- Cognitive impairment -- Menopause -- Metabolic profile; Menopause -- Periodicals; 618.175005
• DOI: 10.1097/GME.0000000000001160
• Languages: English
• ISSNs: 1072-3714

Abstract

Abstract: Objective: We hypothesized the association of metabolic profile on cognition in postmenopausal women will be greater among ApoE4 carriers compared with noncarriers. Methods: Metabolic biomarkers and measures of global cognition, executive functions, and verbal memory, collected among postmenopausal females, were used in this analysis. Clustering analyses of metabolic biomarkers revealed three phenotypes: healthy, predominantly hypertensive, and poor metabolic with (borderline normal laboratory values). General linear models tested whether an association of metabolic cluster with cognition differed by ApoE4 genotype. Results: In the total sample of 497 women, verbal memory was lower in the poor metabolic cluster ( P = 0.04). Among ApoE4+ women, performance in all cognitive domains was lowest in the poor metabolic cluster. Differences in executive functions among metabolic clusters were detected only in ApoE4+ women ( P value for interaction = 0.003). Conclusions: In a general population of postmenopausal women, association between poor metabolic profile with reduction in cognitive performance is more apparent in women who carry an ApoE4 allele. These data indicate a window of opportunity for interventions to reverse the trajectory of the preclinical phase of Alzheimer's disease. Abstract : Supplemental Digital Content is available in the text