Brain Metastases of a Neuroendocrine Tumor Visualized by 68Ga-DOTATATE PET/CT. (January 2019)

• Record Type: Journal Article
• Authors: Hoberück, Sebastian; Michler, Enrico; Zöphel, Klaus; Platzek, Ivan; Kotzerke, Jörg; Brogsitter, Claudia
• Is Part Of: Clinical nuclear medicine. Volume 44:Number 1(2019)
• Publication Date: 2019-01
• Subjects: brain metastases -- cerebral metastases -- 68Ga -- PRRT -- NET -- neuroendocrine tumor -- DOTA; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002341
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 65-year-old woman with a long history of metastasized, highly differentiated (G1) neuroendocrine tumor of pancreatic origin presented for follow-up 68 Ga-DOTATATE PET/CT after 7 peptide receptor radiotherapies. In the previous scan, she already had discrete intracranial tracer accumulations, which were massively progressive in the recent 68 Ga-DOTATATE PET/CT 8 months later. This case illustrates that cerebral metastases in neuroendocrine tumors may occur many years after initial diagnosis, and their somatostatin receptor expression may rise within a few months to a level that reasonably justifies further peptide receptor radiotherapy.